Tina Ritschel Selected Research

queuine tRNA-ribosyltransferase

9/2013	High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
12/2009	How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase.
10/2009	High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.
3/2009	Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT.

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Tina Ritschel Research Topics

Disease

5	Bacillary Dysentery (Shigellosis) 09/2013 - 03/2009
2	Inflammation (Inflammations) 01/2019 - 02/2015
2	Muscular Diseases (Myopathy) 11/2015 - 09/2015
2	Foodborne Diseases 09/2013 - 07/2012
1	Human Influenza (Influenza) 01/2022
1	Cerebrotendinous Xanthomatosis 01/2019
1	Carcinogenesis 01/2019
1	Gallstones (Gallstone) 01/2019
1	Constipation 01/2019
1	Respiratory Syncytial Virus Infections 01/2018
1	Infections 01/2018
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2018
1	Neoplasms (Cancer) 01/2017
1	Obesity 09/2015
1	Myotoxicity 09/2015
1	Peritonitis 02/2015
1	Sepsis (Septicemia) 02/2015
1	Cholestasis 05/2014

Drug/Important Bio-Agent (IBA)

4	Pharmaceutical PreparationsIBA 01/2019 - 09/2013
4	queuine tRNA-ribosyltransferaseIBA 09/2013 - 03/2009
3	EnzymesIBA 09/2015 - 10/2009
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2009
2	VaccinesIBA 01/2022 - 01/2018
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 11/2015 - 09/2015
2	Transfer RNA (tRNA)IBA 09/2013 - 10/2009
1	Hemagglutinins (Hemagglutinin)IBA 01/2022
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2022
1	Chenodeoxycholic Acid (Chenix)FDA Link 01/2019
1	Bile Acids and Salts (Bile Acids)IBA 01/2019
1	fragilysinIBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	Bacteroides fragilis toxinIBA 01/2019
1	AntibodiesIBA 01/2018
1	Complement System Proteins (Complement)IBA 01/2018
1	Glycoproteins (Glycoprotein)IBA 01/2018
1	Sialic Acid Binding Immunoglobulin-like LectinsIBA 01/2017
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2017
1	ibipinabantIBA 09/2015
1	Adenosine Triphosphate (ATP)IBA 09/2015
1	Adenosine Diphosphate (ADP)IBA 09/2015
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 09/2015
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 09/2015
1	Member 11 Subfamily B ATP Binding Cassette TransporterIBA 05/2014
1	Shiga Toxin (Shigella Toxin)IBA 07/2012
1	LigandsIBA 03/2009

Therapy/Procedure

1	Therapeutics 11/2015